Activating Compound | Comment | Organism | Structure |
---|---|---|---|
pepsin A | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | cathepsin B contributes to the neovascularization process and should be considered as a potential therapeutic target | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074 Me | 99.4% inhibition at 0.010 mM in cell lysates | Homo sapiens | |
N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-proline | CA-074, 40.4% inhibition at 0.010 mM in cell lysates | Homo sapiens | |
trans-epoxysuccinyl-L-leucyl-amido(4-guanidino)butane | E-64, 63.2% inhibition at 0.010 mM in cell lysates | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
lysosome | - |
Homo sapiens | 5764 | - |
additional information | Alexa Fluor 488 labeled intracellular cathepsin B is localized in vesicle-like structures in the perinuclear region of HUVECs | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07858 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUVEC cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0003 | - |
secreted protein in cell culture, in the presence of 0.01 mM E-64 | Homo sapiens |
0.00042 | - |
secreted protein in cell culture, in the presence of 0.01 mM CA-074 | Homo sapiens |
0.00042 | - |
secreted protein in cell culture, in the presence of 0.01 mM CA-074 Me | Homo sapiens |
0.00225 | - |
in the presence of 0.01 mM CA-074 Me in cell lysates | Homo sapiens |
0.1027 | - |
in the presence of 0.01 mM E-64 in cell lysates | Homo sapiens |
0.1468 | - |
in the presence of 0.01 mM CA-074 in cell lysates | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Z-Arg-Arg-cresyl violet + H2O | - |
Homo sapiens | Z-Arg-Arg + cresyl violet | - |
? | |
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O | - |
Homo sapiens | Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin B | - |
Homo sapiens |