Activating Compound | Comment | Organism | Structure |
---|---|---|---|
asparaginyl endopeptidase from Schistosoma mansoni | - |
Trichobilharzia regenti |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Trichobilharzia regenti |
expression in Escherichia coli, expressed as zymogen in Pichia pastoris | Trichobilharzia regenti |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DCG-04 | - |
Trichobilharzia regenti | |
N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-proline | CA-074; CA-074; CA-074; CA-074 | Trichobilharzia regenti | |
trans-epoxysuccinyl-L-leucyl-amido(4-guanidino)butane | E-64; E-64; E-64 | Trichobilharzia regenti | |
trans-epoxysuccinyl-L-leucyl-smido(4-guanidino)butane | E-64 | Trichobilharzia regenti |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
28500 | - |
mature protein, calculated from amino acid sequence | Trichobilharzia regenti |
33000 | - |
x * 33000, SDS-PAGE | Trichobilharzia regenti |
36500 | - |
zymogen protein, calculated from amino acid sequence | Trichobilharzia regenti |
38700 | - |
full length protein, calculated from amino acid sequence | Trichobilharzia regenti |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trichobilharzia regenti | Q4VRW4 | - |
- |
Trichobilharzia regenti | Q4VRW5 | - |
- |
Trichobilharzia regenti | Q4VRW6 | - |
- |
Trichobilharzia regenti | Q4VRW7 | - |
- |
Trichobilharzia regenti | Q4VRW8 | - |
- |
Trichobilharzia regenti | Q4VRW9 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Trichobilharzia regenti |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-phenylalanyl-arginine-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, activity at pH 5.0 is 80fold greater than with Arg-Arg | Trichobilharzia regenti | Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
additional information | no degradation of hemoglobin | Trichobilharzia regenti | ? | - |
? | |
additional information | this isoform encodes an inactive enzyme | Trichobilharzia regenti | ? | - |
? | |
myelin basic protein + H2O | - |
Trichobilharzia regenti | ? | - |
? | |
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature | Trichobilharzia regenti | Z-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, least preferred substrate | Trichobilharzia regenti | Z-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, negligible hydrolysis | Trichobilharzia regenti | Z-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
Z-Arg-Leu-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature | Trichobilharzia regenti | Z-Arg-Leu + 7-amino-4-methylcoumarin | - |
? | |
Z-Arg-Leu-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, less than 25% hydrolysis compared to Z-Arg-Val-7-amido-4-methylcoumarin | Trichobilharzia regenti | Z-Arg-Leu + 7-amino-4-methylcoumarin | - |
? | |
Z-Arg-Phe-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature | Trichobilharzia regenti | Z-Arg-Phe + 7-amino-4-methylcoumarin | - |
? | |
Z-Arg-Phe-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, less than 25% hydrolysis compared to Z-Arg-Val-7-amido-4-methylcoumarin | Trichobilharzia regenti | Z-Arg-Phe + 7-amino-4-methylcoumarin | - |
? | |
Z-Arg-Val-7-amido-4-methylcoumarin + H2O | 2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, preferred substrate | Trichobilharzia regenti | Z-Arg-Val + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 33000, SDS-PAGE | Trichobilharzia regenti |
Synonyms | Comment | Organism |
---|---|---|
cathepsin B | isoform 1 | Trichobilharzia regenti |
cathepsin B | isoform 2 | Trichobilharzia regenti |
cathepsin B | isoform 3 | Trichobilharzia regenti |
cathepsin B | isoform 4 | Trichobilharzia regenti |
cathepsin B | isoform 5 | Trichobilharzia regenti |
cathepsin B | isoform 6 | Trichobilharzia regenti |
TrCB1.1 | - |
Trichobilharzia regenti |
TrCB1.2 | - |
Trichobilharzia regenti |
TrCB1.3 | - |
Trichobilharzia regenti |
TrCB1.4 | - |
Trichobilharzia regenti |
TrCB1.5 | - |
Trichobilharzia regenti |
TrCB1.6 | - |
Trichobilharzia regenti |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | 6.5 | with Z-Arg-Phe-7-amido-4-methylcoumarin, Z-Arg-Val-7-amido-4-methylcoumarin or Z-Arg-Leu-7-amido-4-methylcoumarin as substrate | Trichobilharzia regenti |
4.5 | 5.5 | with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Trichobilharzia regenti |
5 | 6.5 | with Z-Arg-Val-7-amido-4-methylcoumarin as substrate | Trichobilharzia regenti |
5.5 | 6.5 | with Z-Arg-Arg-7-amido-4-methylcoumarin as substrate | Trichobilharzia regenti |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4 | 7 | when myelin basic protein is used as substrate | Trichobilharzia regenti |