Literature summary for 3.4.22.1 extracted from

Cathers, B.E.; Barrett, C.; Palmer, J.T.; Rydzewski, R.M.
pH Dependence of inhibitors targeting the occluding loop of cathepsin B (2002), Bioorg. Chem., 30, 264-275.

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Inhibitors

Inhibitors	Comment	Organism	Structure
APC-3316	kinetics, pH-dependence of inhibition	Homo sapiens
APC-5840	kinetics, pH-dependence of inhibition	Homo sapiens
APC-8754	kinetics, pH-dependence of inhibition	Homo sapiens
E64	kinetics, pH-dependence of inhibition	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.3	-	Boc-L-Leu-L-Lys-L-Arg-4-methylcoumaryl-7-amide	22°C, value is quite stable in the range of pH 4.0 to pH 7.8	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	commercial preparation	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Boc-L-Leu-L-Lys-L-Arg-4-methylcoumarin-7-amide + H2O	pH-dependence of reaction	Homo sapiens	Boc-L-Leu-L-Lys-L-Arg + 7-amino-4-methylcoumarin	-	?

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Release 2023.1 (January 2023)