Any feedback?
Literature summary for 3.4.22.1 extracted from
- Biochemical properties of purified cathepsin B from Schistosoma mansoni (1995), Int. J. Parasitol., 25, 1515-1519.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | activates | Schistosoma mansoni |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzyloxycarbonyl-Leu-Leu-Tyr-CHN2 | - |
Schistosoma mansoni | |
| benzyloxycarbonyl-Trp-Met-CHN2 | - |
Schistosoma mansoni | |
| L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane | E-64 | Schistosoma mansoni | |
| L-trans-epoxysuccinyl-3,5-diiodo-L-tyrosylamido(3-methyl)-butane | compound 13b | Schistosoma mansoni | |
| L-trans-epoxysuccinyl-3,5-diiodo-L-tyrosylamido(3-methyl)-butane ethylester | compound 13a | Schistosoma mansoni | |
| N-(L-3-trans-carboxyoxirane-2-carbonyl)-Ile-Pro | CA-030 | Schistosoma mansoni | |
| N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-Ile-Pro | CA-074 | Schistosoma mansoni | |
| peptidyl diazomethyl ketone derivatives | peptidyl diazomethanes | Schistosoma mansoni |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide | - |
Schistosoma mansoni | |
| 0.041 | - |
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide | - |
Schistosoma mansoni | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Proteins + H2O | Schistosoma mansoni | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schistosoma mansoni | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Schistosoma mansoni |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O | - |
Schistosoma mansoni | benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
| benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide | - |
Schistosoma mansoni | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
| globin + H2O | - |
Schistosoma mansoni | partially degraded globin | - |
? | |
| Proteins + H2O | - |
Schistosoma mansoni | ? | - |
? | |
| serum albumin + H2O | - |
Schistosoma mansoni | partially degraded serum albumin | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 12.2 | - |
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide | - |
Schistosoma mansoni | |
| 49.5 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide | - |
Schistosoma mansoni | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 5 | globin degradation | Schistosoma mansoni |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
