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Literature summary for 3.4.22.1 extracted from

  • MacGregor, R.R.; Hamilton, J.W.; Shofstall, R.E.; Cohn, D.V.
    Isolation and characterization of porcine parathyroid cathepsin B (1979), J. Biol. Chem., 254, 4423-4427.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
antipain
-
Sus scrofa
Hg2+
-
Sus scrofa
iodoacetamide
-
Sus scrofa
iodoacetic acid
-
Sus scrofa
leupeptin
-
Sus scrofa
N-ethylmaleimide
-
Sus scrofa
Zn2+
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide
-
Sus scrofa
1.25
-
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Proteins + H2O Sus scrofa turnover of intracellular proteins ?
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-
parathyroid gland
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
-
Sus scrofa benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
-
Sus scrofa ? + 4-methoxy-beta-naphthylamine
-
?
Proteins + H2O turnover of intracellular proteins Sus scrofa ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
68
-
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide
-
Sus scrofa
87
-
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7
-
Sus scrofa

pH Stability

pH Stability pH Stability Maximum Comment Organism
4.5 7.5 unstable above and below Sus scrofa