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Literature summary for 3.4.22.1 extracted from
- Comparative studies of mouse liver cathepsin B and an analogous tumor thiol proteinase (1983), J. Biol. Chem., 258, 11049-11056.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antipain | - |
Mus musculus |  |
| Chloroquine | - |
Mus musculus | |
| Elastatinal | - |
Mus musculus | |
| iodoacetic acid | - |
Mus musculus | |
| leupeptin | - |
Mus musculus | |
| Peptidyl chloromethylketones | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0232 | - |
benzoyl-Phe-Val-Arg-p-nitroanilide | liver enzyme | Mus musculus | |
| 0.0561 | - |
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide | tumor enzyme | Mus musculus | |
| 0.07 | - |
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide | liver enzyme and tumor enzyme | Mus musculus | |
| 0.091 | - |
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide | liver enzyme | Mus musculus | |
| 0.18 | - |
benzoyl-Phe-Val-Arg-p-nitroanilide | tumor enzyme | Mus musculus | |
| 0.2 | - |
benzoyl-Pro-Phe-Arg-p-nitroanilide | liver enzyme | Mus musculus | |
| 0.59 | - |
benzoyl-Pro-Phe-Arg-p-nitroanilide | tumor enzyme | Mus musculus | |
| 6.7 | - |
benzoyl-DL-Arg-beta-naphthylamide | tumor enzyme | Mus musculus | |
| 24 | - |
benzoyl-DL-Arg-beta-naphthylamide | liver enzyme | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Proteins + H2O | Mus musculus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibrosarcoma cell | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzoyl-DL-Arg-beta-naphthylamide + H2O | - |
Mus musculus | benzoyl-DL-Arg + beta-naphthylamine | - |
? | |
| benzoyl-Phe-Val-Arg-p-nitroanilide + H2O | - |
Mus musculus | benzoyl-Phe-Val-Arg + p-nitroaniline | - |
? | |
| benzoyl-Pro-Phe-Arg-p-nitroanilide + H2O | - |
Mus musculus | benzoyl-Pro-Phe-Arg + p-nitroaniline | - |
? | |
| benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O | - |
Mus musculus | benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine | - |
? | |
| benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O | - |
Mus musculus | ? + 4-methoxy-beta-naphthylamine | - |
? | |
| Proteins + H2O | - |
Mus musculus | ? | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7 | - |
Mus musculus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 7 | stable | Mus musculus |
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