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Literature summary for 3.4.21.26 extracted from
- Alkaloids from Peumus boldus and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity (2015), Nat. Prod. Commun., 10, 577-580 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Berberine | - |
Homo sapiens |  |
| boldine | - |
Homo sapiens | |
| galanthamine | - |
Homo sapiens | |
| isocorydine | - |
Homo sapiens | |
| laurotetanine | - |
Homo sapiens | |
| additional information | not inhibited by huperzine A | Homo sapiens | |
| N-methyllaurotetanine | - |
Homo sapiens | |
| norisocorydine | - |
Homo sapiens | |
| pallidine | - |
Homo sapiens | |
| reticuline | - |
Homo sapiens | |
| sinoacutine | - |
Homo sapiens | |
| Z-prolyl-prolinal | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Z-Gly-L-Pro-4-nitroanilide + H2O | - |
Homo sapiens | Z-Gly-L-Pro + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| POP | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.1354 | - |
pH and temperature not specified in the publication | Homo sapiens | N-methyllaurotetanine | |
| 0.1423 | - |
pH and temperature not specified in the publication | Homo sapiens | Berberine | |
| 0.1431 | - |
pH and temperature not specified in the publication | Homo sapiens | sinoacutine | |
| 0.3204 | - |
pH and temperature not specified in the publication | Homo sapiens | norisocorydine | |
| 0.3923 | - |
pH and temperature not specified in the publication | Homo sapiens | reticuline | |
| 0.5224 | - |
pH and temperature not specified in the publication | Homo sapiens | laurotetanine | |
| 0.5897 | - |
pH and temperature not specified in the publication | Homo sapiens | pallidine | |
| 0.6028 | - |
pH and temperature not specified in the publication | Homo sapiens | boldine | |
| 1 | - |
IC50 above 1.0 mM, pH and temperature not specified in the publication | Homo sapiens | galanthamine | |
| 1 | - |
IC50 above 1.0 mM, pH and temperature not specified in the publication | Homo sapiens | isocorydine | |
| 2.8 | - |
pH and temperature not specified in the publication | Homo sapiens | Z-prolyl-prolinal | |
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Release 2023.1 (January 2023)
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