Literature summary for 3.4.21.26 extracted from

Cahlikova, L.; Hulova, L.; Hrabinova, M.; Chlebek, J.; Hostalkova, A.; Adamcova, M.; Safratova, M.; Jun, D.; Opletal, L.; Locarek, M.; Macakova, K.
Isoquinoline alkaloids as prolyl oligopeptidase inhibitors (2015), Fitoterapia, 103, 192-196 .

Search for more literature for 3.4.21.26

Inhibitors

Inhibitors	Comment	Organism	Structure
argemonine	-	Homo sapiens
Berberine	-	Homo sapiens
californidine	-	Homo sapiens
canadine	-	Homo sapiens
corynoline	-	Homo sapiens
corypalmine	-	Homo sapiens
dihydrosanquinarine	-	Homo sapiens
N-methyllaurotetanine	-	Homo sapiens
platycerine	-	Homo sapiens
reticuline	-	Homo sapiens
Z-prolyl-prolinal	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Homo sapiens	benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
POP	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.056	-	at pH 7.4 and 37°C	Homo sapiens	californidine
0.099	-	at pH 7.4 and 37°C	Homo sapiens	dihydrosanquinarine
0.128	-	at pH 7.4 and 37°C	Homo sapiens	corypalmine
0.135	-	at pH 7.4 and 37°C	Homo sapiens	N-methyllaurotetanine
0.142	-	at pH 7.4 and 37°C	Homo sapiens	Berberine
0.152	-	at pH 7.4 and 37°C	Homo sapiens	canadine
0.289	-	at pH 7.4 and 37°C	Homo sapiens	corynoline
0.337	-	at pH 7.4 and 37°C	Homo sapiens	argemonine
0.392	-	at pH 7.4 and 37°C	Homo sapiens	reticuline
0.687	-	at pH 7.4 and 37°C	Homo sapiens	platycerine
2.75	-	at pH 7.4 and 37°C	Homo sapiens	Z-prolyl-prolinal

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)