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Literature summary for 3.4.21.26 extracted from

  • Klimaviciusa, L.; Jain, R.K.; Jaako, K.; Van Elzen, R.; Gerard, M.; van Der Veken, P.; Lambeir, A.M.; Zharkovsky, A.
    In situ prolyl oligopeptidase activity assay in neural cell cultures (2012), J. Neurosci. Methods, 204, 104-110.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile KYP-2047, most potent inhibitor Homo sapiens
(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile KYP-2047, most potent inhibitor Rattus norvegicus
Boc-Asn-Phe-Pro-aldehyde
-
Homo sapiens
Boc-Asn-Phe-Pro-aldehyde
-
Rattus norvegicus
Z-Pro-Pro-aldehyde-dimethylacetal
-
Homo sapiens
Z-Pro-Pro-aldehyde-dimethylacetal
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
x * 80000, SDS-PAGE Homo sapiens
80000
-
x * 80000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
-
Rattus norvegicus
-
SH-SY5Y cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-benzyl 2-(2-(4-hydroxynaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-2-oxoethylcarbamate + H2O specific substrate, UAMC-00682 Homo sapiens ?
-
?
(S)-benzyl 2-(2-(4-hydroxynaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-2-oxoethylcarbamate + H2O specific substrate, UAMC-00682 Rattus norvegicus ?
-
?
Gly-L-Pro-4-nitroanilide + H2O
-
Homo sapiens Gly-L-Pro + 4-nitroaniline
-
?
Gly-L-Pro-4-nitroanilide + H2O
-
Rattus norvegicus Gly-L-Pro + 4-nitroaniline
-
?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Homo sapiens
? x * 80000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
PREP
-
Homo sapiens
PREP
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000029
-
cell free assay, pH and temperature not specified in the publication Rattus norvegicus (S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
0.00001
-
in situ assay, pH and temperature not specified in the publication Homo sapiens (S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
0.000733
-
cell free assay, pH and temperature not specified in the publication Rattus norvegicus Z-Pro-Pro-aldehyde-dimethylacetal
0.00204
-
cell free assay, pH and temperature not specified in the publication Rattus norvegicus Boc-Asn-Phe-Pro-aldehyde
0.00294
-
in situ assay, pH and temperature not specified in the publication Homo sapiens Boc-Asn-Phe-Pro-aldehyde
0.005111
-
in situ assay, pH and temperature not specified in the publication Homo sapiens Z-Pro-Pro-aldehyde-dimethylacetal