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Literature summary for 3.4.21.26 extracted from

  • Myoehaenen, T.T.; Tenorio-Laranga, J.; Jokinen, B.; Vazquez-Sanchez, R.; Moreno-Baylach, M.J.; Garcia-Horsman, J.A.; Maennistoe, P.T.
    Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner (2011), Br. J. Pharmacol., 163, 1666-1678.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
4-phenyl-butanoyl-L-prolyl-2(S)-cyanopyrrolidine KYP-2047 Homo sapiens
4-phenyl-butanoyl-L-prolyl-2(S)-cyanopyrrolidine KYP-204, 0.1 mM and 0.5 mM concentrations significantly inhibit enzyme activity in tissue homogenate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymosin beta4 + H2O Homo sapiens
-
 acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the recombinant prolyl oligopeptidase is not able to cleave whole 43-mer thymosin beta4, while it is effective at hydrolyzing somatostatin-28 (1-12) Rattus norvegicus ?
-
 ?
N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin
-
 ?
somatostatin-28 (1-12) + H2O
-
 Rattus norvegicus ?
-
 ?
thymosin beta4 + H2O
-
 Homo sapiens acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro + ?
-
 ?
thymosin beta4 + H2O prolyl oligopeptidase is a second-step enzyme in the release of acetyl-N-Ser-Asp-Lys-Pro from thymosin beta4 and has autoregulatory effect in the first step Rattus norvegicus acetyl-N-Ser-Asp-Lys-Pro + ?
-
 ?

Synonyms

Synonyms Comment Organism
POP
-
 Homo sapiens
POP
-
 Rattus norvegicus

General Information

General Information Comment Organism
metabolism prolyl oligopeptidase is a second-step enzyme in the release of acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro from thymosin beta4, and it has autoregulatory effect in the first step Homo sapiens
physiological function prolyl oligopeptidase has a pro-angiogenic role via the release of acetyl-N-Ser-Asp-Lys-Pro from its precursor thymosin beta4 Rattus norvegicus
physiological function prolyl oligopeptidase with thymosin beta4 significantly induces angiogenesis of human umbilical vein endothelial cells. Prolyl oligopeptidase has a pro-angiogenic role via the release of acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro from its precursor thymosin beta4 Homo sapiens