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Literature summary for 3.4.21.26 extracted from

  • Brandt, I.; Gerard, M.; Sergeant, K.; Devreese, B.; Baekelandt, V.; Augustyns, K.; Scharpe, S.; Engelborghs, Y.; Lambeir, A.M.
    Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein (2008), Peptides, 29, 1472-1478.
    View publication on PubMed

Application

Application Comment Organism
medicine positive effect of prolyl oligopeptidase inhibitors on learning and memory in animal models for amnesia, enzyme activity measurements in patient samples and (neuro)peptide degradation studies link the enzyme with neurodegenerative disorders Sus scrofa

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain JM109 Sus scrofa

Protein Variants

Protein Variants Comment Organism
S544A mutant, lacking prolyl oligopeptidase activity Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
UAMC-00021
-
Sus scrofa
Z-Pro-prolinal with high potency but relatively poor stability Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa stimulates the aggregation of alpha-synuclein ?
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information stimulates the aggregation of alpha-synuclein Sus scrofa ?
-
?
Z-Gly-Pro-p-nitroanilide + H2O
-
Sus scrofa Z-Gly-Pro + p-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
prolyl oligopeptidase
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000016
-
-
Sus scrofa UAMC-00021