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Literature summary for 3.4.21.26 extracted from

  • Jarho, E.M.; Venaelaeinen, J.I.; Poutiainen, S.; Leskinen, H.; Vepsaelaeinen, J.; Christiaans, J.A.; Forsberg, M.M.; Maennistoe, P.T.; Wallen, E.A.
    2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors (2007), Bioorg. Med. Chem., 15, 2024-2031.
    View publication on PubMed
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
1-(4-phenylbutanoyl)-2(S)-(pyridine-2-carbonyl)pyrrolidine
-
 Sus scrofa
1-(4-phenylbutanoyl)-2(S)-(thiophene-2-carbonyl)pyrrolidin
-
 Sus scrofa
1-(cyclopent-1-enecarbonyl)-D-proline benzylamide
-
 Sus scrofa
1-(cyclopent-1-enecarbonyl)-L-proline benzylamide
-
 Sus scrofa
1-(cyclopent-1-enecarbonyl)-L-proline phenethylamide
-
 Sus scrofa
2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines
-
 Sus scrofa
2(S)-(cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines
-
 Sus scrofa
2(S)-(cyclohex-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine
-
 Sus scrofa
2(S)-(cyclopent-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine
-
 Sus scrofa
2(S)-(furan-2-carbonyl)-1-(4-phenylbutanoyl)pyrrolidine
-
 Sus scrofa
additional information inhibitor synthesis, overview Sus scrofa
SUAM-1221
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Sus scrofa 5829
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information POP is a proline-specific peptidase that hydrolyzes oligopeptides after prolyl residues, the S1 binding site of POP has evolved to fit the pyrrolidine ring of an L-prolyl residue Sus scrofa ?
-
 ?
N-succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O
-
 Sus scrofa N-succinyl-Gly-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
POP
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
 pH 7.0, 30°C Sus scrofa 2(S)-(cyclopent-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine
0.000003
-
 pH 7.0, 30°C Sus scrofa 1-(4-phenylbutanoyl)-2(S)-(thiophene-2-carbonyl)pyrrolidin
0.0000052
-
 pH 7.0, 30°C Sus scrofa 2(S)-(furan-2-carbonyl)-1-(4-phenylbutanoyl)pyrrolidine
0.000059
-
 pH 7.0, 30°C Sus scrofa 2(S)-(cyclohex-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine
0.0001
-
 pH 7.0, 30°C Sus scrofa 1-(cyclopent-1-enecarbonyl)-L-proline phenethylamide
0.00021
-
 pH 7.0, 30°C Sus scrofa 1-(cyclopent-1-enecarbonyl)-L-proline benzylamide
0.00051
-
 pH 7.0, 30°C Sus scrofa 1-(4-phenylbutanoyl)-2(S)-(pyridine-2-carbonyl)pyrrolidine
0.044
-
 pH 7.0, 30°C Sus scrofa 1-(cyclopent-1-enecarbonyl)-D-proline benzylamide