Literature summary for 3.4.21.26 extracted from

Park, Y.S.; Jang, H.J.; Lee, K.H.; Hahn, T.R.; Paik, Y.S.
Prolyl endopeptidase inhibitory activity of unsaturated fatty acids (2006), J. Agric. Food Chem., 54, 1238-1242.

Search for more literature for 3.4.21.26

Application

Application	Comment	Organism
medicine	enzyme levels in postmortem brains of Alzheimers disease patients reveal significant increases in enzyme activity. Use of unsaturated fatty acids in preventing memory loss	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
arachidonic acid	50% inhibition at 0.0534 mM	Homo sapiens
docosahexaenoic acid	50% inhibition at 0.0462 mM	Homo sapiens
eicosapentaenoic acid	50% inhibition at 0.0994 mM	Homo sapiens
linoleic acid	50% inhibition at 0.0438 mM	Homo sapiens
oleic acid	50% inhibition at 0.0236 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with Alzheimers disease	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Homo sapiens	?	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0267	-	oleic acid	37°C, pH 7.0	Homo sapiens
0.051	-	linoleic acid	37°C, pH 7.0	Homo sapiens
0.089	-	docosahexaenoic acid	37°C, pH 7.0	Homo sapiens
0.0913	-	arachidonic acid	37°C, pH 7.0	Homo sapiens
0.2475	-	eicosapentaenoic acid	37°C, pH 7.0	Homo sapiens

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Release 2023.1 (January 2023)