Literature summary for 3.4.21.26 extracted from

Olivo, R.d.o.A.; Teixeira, C.d.e.F.; Silveira, P.F.
Representative aminopeptidases and prolyl endopeptidase from murine macrophages: comparative activity levels in resident and elicited cells (2005), Biochem. Pharmacol., 69, 1441-1450.

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Activating Compound

Activating Compound	Comment	Organism	Structure
NaCl	slight activation	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
amastatin	0.1 mM, 97% inhibition	Mus musculus
bestatin	0.5 mM, 97% inhibition	Mus musculus
diprotin	0.1 mM, complete inhibition	Mus musculus
puromycin	0.1 mM, 97% inhibition	Mus musculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0014	-	benzyloxycarbonyl-Gly-L-Pro-beta-naphthylamide	pH 7.4, 37°C, enzyme from thioglycollate-elicited macrophage	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	male animal	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	resident and elicited macrophage	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Gly-L-Pro-beta-naphthylamide + H2O	-	Mus musculus	?	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
4.7	-	benzyloxycarbonyl-Gly-L-Pro-beta-naphthylamide	pH 7.4, 37°C, enzyme from thioglycollate-elicited macrophage	Mus musculus

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Release 2023.1 (January 2023)