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Literature summary for 3.4.21.26 extracted from

  • Quinto, B.M.; Juliano, M.A.; Hirata, I.; Carmona, A.K.; Juliano, L.; Casarini, D.E.
    Characterization of a prolyl endopeptidase (kininase) from human urine using fluorogenic quenched substrates (2000), Int. J. Biochem. Cell Biol., 32, 1161-1172.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol
-
Homo sapiens
benzyloxycarbonyl-Pro-prolinal
-
Homo sapiens
Co2+
-
Homo sapiens
dithiothreitol
-
Homo sapiens
EDTA
-
Homo sapiens
Hg2+
-
Homo sapiens
additional information resistant to: PMSF, thyorphan, E64 and phosphoramidon Homo sapiens
o-phenanthroline
-
Homo sapiens
p-hydroxymercuribenzoate
-
Homo sapiens
PCMB
-
Homo sapiens
Zn2+
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00065
-
2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) pH 8.0, 37°C Homo sapiens
0.00074
-
2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) pH 8.0, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
urine
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-FFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
Homo sapiens 2-aminobenzoyl-FP + Q-(N-(2,4-dinitrophenyl)ethylenediamine)
-
?
2-aminobenzoyl-FSQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-RPPGFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
Homo sapiens ?
-
?
2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
Homo sapiens 2-aminobenzoyl-RPP + GFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
?
2-aminobenzoyl-SPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
-
Homo sapiens ?
-
?
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O as active as potentiator B Homo sapiens Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
-
?
Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O as active as potentiator B Homo sapiens Met-Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
-
?
additional information no activity with Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr and pGly-His-Trp-Ser-tyr-Gly-leu-Arg-Pro-Gly-NH2 Homo sapiens ?
-
?
pGlu-Gly-Leu-Pro-Pro-Arg-Pro + H2O i.e. potentiator B Homo sapiens pGlu-Gly-Leu-Pro-Pro + Arg-Pro
-
?
pGlu-Gly-Leu-Pro-Pro-Gly-Pro + H2O i.e. potentiator C, as active as potentiator B Homo sapiens pGlu-Gly-Leu-Pro-Pro + Gly-Pro
-
?
RPPGFSPFR + H2O i.e. bradykinin, 90% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro Homo sapiens ?
-
?
RPPGFSPFR-amide + H2O i.e. bradykinin, 70% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro Homo sapiens RPP + GFSPFR-amide
-
?

Synonyms

Synonyms Comment Organism
PE
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
reaction with 2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine), and a second lower optimum at pH 8.0 Homo sapiens
8
-
reaction with bradykinin. And a second higher optimum at pH 6.5, reaction with 2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) Homo sapiens
9
-
reaction with 2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 9 pH 7.0: about 55% of maximal activity, pH 9.0: about 30% of maximal activity, reaction with bradykinin Homo sapiens
8.5 10 pH 8.5: about 40% of maximal activity, pH 10.0: about 80% of maximal activity, reaction with 2-aminobenzoyl-BKQRPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) Homo sapiens