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Literature summary for 3.4.21.26 extracted from

  • Kim, J.H.; Kim, S.I.; Song, K.S.
    Prolyl endopeptidase inhibitors from green tea (2001), Arch. Pharm. Res., 24, 292-296.
    View publication on PubMed

Application

Application Comment Organism
medicine the inhibitors (-)-epigallocatechin gallate, (-)-epicatechin gallate and (+)-gallocatechin are expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica

Inhibitors

Inhibitors Comment Organism Structure
(+)-gallocatechin IC50: 0.000109 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica
(-)-epicatechin gallate IC50: 10.2 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica
(-)-epigallocatechin gallate IC50: 0.000142 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica

Organism

Organism UniProt Comment Textmining
Elizabethkingia meningoseptica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O
-
Elizabethkingia meningoseptica benzyloxycarbonyl-Gly-Pro + p-nitroaniline
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000109
-
IC50: 0.000109 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica (+)-gallocatechin
0.000142
-
IC50: 0.000142 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica (-)-epigallocatechin gallate
10.2
-
IC50: 10.2 mM, expected to be useful for preventing and curing of Alzheimer‘s disease Elizabethkingia meningoseptica (-)-epicatechin gallate