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Literature summary for 3.4.21.26 extracted from

  • Chen, Y.S.; Christensen, J.E.; Broadbent, J.R.; Steele, J.L.
    Identification and characterization of Lactobacillus helveticus PepO2, an endopeptidase with post-proline specificity (2003), Appl. Environ. Microbiol., 69, 1276-1282.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.26

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc the enzyme contains the zinc-dependent metalloprotease motif HEXXH Lactobacillus helveticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Lactobacillus helveticus the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209) ?
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 ?
additional information Lactobacillus helveticus CNRZ32 the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209) ?
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 ?

Organism

Organism UniProt Comment Textmining
Lactobacillus helveticus Q8VTS9 CNRZ32
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Lactobacillus helveticus CNRZ32 Q8VTS9 CNRZ32
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Pro-Lys-His-Pro-Ile-Lys-His-Gln + H2O i.e. alphaS1-casein(1-9), cleavage at Pro5-Ile6 Lactobacillus helveticus Arg-Pro-Lys-His-Pro + Ile-Lys-His-Gln
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 ?
Arg-Pro-Lys-His-Pro-Ile-Lys-His-Gln + H2O i.e. alphaS1-casein(1-9), cleavage at Pro5-Ile6 Lactobacillus helveticus CNRZ32 Arg-Pro-Lys-His-Pro + Ile-Lys-His-Gln
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 ?
additional information the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209) Lactobacillus helveticus ?
-
 ?
additional information the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209) Lactobacillus helveticus CNRZ32 ?
-
 ?
Tyr-Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-p-nitroanilide + H2O i.e. N-acetyl-beta-casein-(f203-209)-p-nitroanilide, cleavage at: Pro196-Val197, Pro200-Val201 and Pro206-Ile207 Lactobacillus helveticus ?
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 ?
Tyr-Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-p-nitroanilide + H2O i.e. N-acetyl-beta-casein-(f203-209)-p-nitroanilide, cleavage at: Pro196-Val197, Pro200-Val201 and Pro206-Ile207 Lactobacillus helveticus CNRZ32 ?
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 ?

Synonyms

Synonyms Comment Organism
PepO2
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 Lactobacillus helveticus
post-proline endopeptidase
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 Lactobacillus helveticus