Literature summary for 3.4.19.12 extracted from

Kang, S.J.; Kim, J.S.; Park, S.M.
Ubiquitin C-terminal hydrolase L1 regulates lipid raft-dependent endocytosis (2018), Exp. Neurobiol., 27, 377-386 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09936	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	the enzyme is highly expressed in neurons	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ubiquitin C-terminal hydrolase L1	-	Homo sapiens
UCH-L1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	UCH-L1 associates with lipid rafts as with other Parkinson's disease-associated gene products. In addition, UCH-L1 regulates lipid raft-dependent endocytosis and it is not dependent on the expression and degradation of caveolin-1 or flotillin-1. UCH-L1 regulates cell-to-cell transmission of alpha-synuclein. The study provides evidence that many Parkinson's disease-associated gene products share common signaling pathways to explain the pathogenesis of Parkinson's disease	Homo sapiens
physiological function	UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease	Homo sapiens

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Release 2023.1 (January 2023)