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Literature summary for 3.4.19.12 extracted from
- Ubiquitin C-terminal hydrolase L1 regulates myoblast proliferation and differentiation (2017), Biochem. Biophys. Res. Commun., 492, 96-102 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9R0P9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| C2C12 cell | - |
Mus musculus | - |
| myoblast | - |
Mus musculus | - |
| skeletal muscle | upregulated in skeletal muscles in disease conditions | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ubiquitin C-terminal hydrolase L1 | - |
Mus musculus |
| UCHL1 | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | UCHL1 protein level is continuously declined during cell differentiation | down |
| Mus musculus | UCHL1 is significantly upregulated in denervated skeletal muscle | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | gene knockdown of UCHL1 by siRNA results in a significant decrease in cell proliferation but marked acceleration of cell differentiation and myotube formation. UCHL1 gene knockdown upregulates myogenic factors myoD and Myogenin (MyoG) | Mus musculus |
| physiological function | UCHL1 may play a role in myogenesis by promoting myoblast proliferation and inhibiting differentiation | Mus musculus |
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Release 2023.1 (January 2023)
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