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Literature summary for 3.4.19.12 extracted from

  • Chipumuro, E.; Henriksen, M.
    The ubiquitin hydrolase USP22 contributes to 3'-end processing of JAK-STAT-inducible genes (2012), FASEB J., 26, 842-854.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
2-fTGH cell
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Homo sapiens
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HeLa cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
USP22
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Homo sapiens

General Information

General Information Comment Organism
physiological function RNAi-mediated knockdown of the ubiquitin hydrolase, USP22, results in 2fold increase in monoubiquitinated histone H2B, and 2fold decrease in transcriptional elongation at IRF1. USP22 depletion diminishes 3'-end cleavage/polyadenylation by 2- to 3fold. The polyadenylation factor CPSF73 is not effectively recruited, and serine 2 phosphorylation of the C-terminal domain of RNA polymerase II is also disrupted. Results suggest that ubiquitinated histone H2B helps recruit polyadenylation factors to STAT1-activated genes Homo sapiens