Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
2-fTGH cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
USP22 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | RNAi-mediated knockdown of the ubiquitin hydrolase, USP22, results in 2fold increase in monoubiquitinated histone H2B, and 2fold decrease in transcriptional elongation at IRF1. USP22 depletion diminishes 3'-end cleavage/polyadenylation by 2- to 3fold. The polyadenylation factor CPSF73 is not effectively recruited, and serine 2 phosphorylation of the C-terminal domain of RNA polymerase II is also disrupted. Results suggest that ubiquitinated histone H2B helps recruit polyadenylation factors to STAT1-activated genes | Homo sapiens |