Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
dUCH | Drosophila homologue of UCH-L1 | Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
physiological function | over-expression of dUCH in the eye imaginal discs induces a rough eye phenotype in the adult, at least partly resulting from the induction of caspase-dependent apoptosis followed by compensatory proliferation. The over-expression of dUCH specifically impairs R7 photoreceptor cell differentiation with a reduction in activated extracellular-signal regulated kinase signals. The dUCH-induced rough eye phenotype is rescued by co-expression of the sevenless gene or the Draf gene, a downstream component of the mitogen-activated protein kinase (MAPK) cascade | Drosophila melanogaster |