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Literature summary for 3.4.19.12 extracted from

  • Thao, D.T.; An, P.N.; Yamaguchi, M.; LinhThuoc, T.
    Overexpression of ubiquitin carboxyl terminal hydrolase impairs multiple pathways during eye development in Drosophila melanogaster (2012), Cell Tissue Res., 348, 453-463.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Synonyms

Synonyms Comment Organism
dUCH Drosophila homologue of UCH-L1 Drosophila melanogaster

General Information

General Information Comment Organism
physiological function over-expression of dUCH in the eye imaginal discs induces a rough eye phenotype in the adult, at least partly resulting from the induction of caspase-dependent apoptosis followed by compensatory proliferation. The over-expression of dUCH specifically impairs R7 photoreceptor cell differentiation with a reduction in activated extracellular-signal regulated kinase signals. The dUCH-induced rough eye phenotype is rescued by co-expression of the sevenless gene or the Draf gene, a downstream component of the mitogen-activated protein kinase (MAPK) cascade Drosophila melanogaster