Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mesangial cell | MES13 cell line | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin C-terminal hydrolase-L5 | - |
Mus musculus |
UCHL5 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | high glucose increases UCHL5 protein expression | up |
General Information | Comment | Organism |
---|---|---|
physiological function | high glucose increases the TGF-betaR1 protein expression via the PI3K-UCHL5 pathway in mesangial cells | Mus musculus |
physiological function | UCHL5 is required for high glucose-induced reduction of TGFbetaR1 protein ubiquitination, p21WAF1 protein expression, cell hypertrophy and fibronectin protein expression | Mus musculus |