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Literature summary for 3.4.19.12 extracted from

  • Bheda, A.; Yue, W.; Gullapalli, A.; Whitehurst, C.; Liu, R.; Pagano, J.S.; Shackelford, J.
    Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling (2009), PLoS ONE, 4, e5955.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.19.12

Cloned(Commentary)

Cloned (Comment) Organism
expression of HA-tagged wild-type and mutant enzymes in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C90S a UCH L1 mutant, that shows no binding to beta-catenin Homo sapiens
H161D a UCH L1 mutant, that shows no binding to beta-catenin Homo sapiens
additional information UCH L1 silencing with siRNAs leads to accumulation of beta-catenin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UCH L1 forms endogenous complexes with beta-catenin and stabilizes it. The expression and deubiquitinating activity of UCHL1 are required for its own basic promoter activity, therefore UCH L1 up-regulates its expression by activation of the oncogenic beta-catenin/TCF signaling in transformed cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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 swiss mice
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Source Tissue

Source Tissue Comment Organism Textmining
KR-4 cell a B lymphoblastoid cell line Homo sapiens
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NIH-3T3 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UCH L1 forms endogenous complexes with beta-catenin and stabilizes it. The expression and deubiquitinating activity of UCHL1 are required for its own basic promoter activity, therefore UCH L1 up-regulates its expression by activation of the oncogenic beta-catenin/TCF signaling in transformed cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ubiquitin C-terminal hydrolase L1
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 Mus musculus
ubiquitin C-terminal hydrolase L1
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 Homo sapiens
UCH L1
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 Mus musculus
UCH L1
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 Homo sapiens

Expression

Organism Comment Expression
Mus musculus treatment with LiCl induces UCH L1 expression in 3T3 cells, no induction by TCF-4, but synergistic effects of TCF-4 and LiCl, TCF4 binds to the endogenous uchl1 promoter up

General Information

General Information Comment Organism
physiological function UCH L1 up-regulates beta-catenin/TCF signaling. UCH L1 forms endogenous complexes with beta-catenin, stabilizes it and up-regulates beta-catenin/TCF-dependent transcription. The deubiquitinating activity of UCH L1 is required for TCF4 transcriptional activity, overview Homo sapiens