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Literature summary for 3.4.19.12 extracted from

  • Goto, A.; Wang, Y.L.; Kabuta, T.; Setsuie, R.; Osaka, H.; Sawa, A.; Ishiura, S.; Wada, K.
    Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse (2009), Neurochem. Int., 54, 330-338.
    View publication on PubMed
Search for more literature for 3.4.19.12

Application

Application Comment Organism
analysis UCH-L1 is a neuronal marker Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information gad, i.e. gracile axonal dystrophy, mice are analogous to a null mutants of UCH-L1, they display the dying-back-type of axonal degeneration in sensory neurons. The level of mono-ubiquitin is decreased in neurons, especially in axons of the sciatic nerve, in gad mice Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25100
-
 x * 25100, UCH-L1, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus UCH-L1 is a deubiquitinating enzyme, it binds to and stabilize mono-ubiquitin in neurons ?
-
 ?
additional information Mus musculus UCH-L1 is a deubiquitinating enzyme, it binds to and stabilizes mono-ubiquitin in neurons ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron high expression of UCH-L1 Mus musculus
-
ovary high expression of UCH-L1 Mus musculus
-
sciatic nerve
-
 Mus musculus
-
testis high expression of UCH-L1 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UCH-L1 is a deubiquitinating enzyme, it binds to and stabilize mono-ubiquitin in neurons Mus musculus ?
-
 ?
additional information UCH-L1 is a deubiquitinating enzyme, it binds to and stabilizes mono-ubiquitin in neurons Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 25100, UCH-L1, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
PGP9.5
-
 Mus musculus
ubiquitin carboxyl-terminal hydrolase L1
-
 Mus musculus
Ubiquitin thiolesterase
-
 Mus musculus
UCH-L1
-
 Mus musculus

pI Value

Organism Comment pI Value Maximum pI Value
Mus musculus UCH-L1, isoelectric focusing
-
 5.12

General Information

General Information Comment Organism
physiological function UCH-L1 is a deubiquitinating enzyme, it binds to and stabilize mono-ubiquitin in neurons Mus musculus
physiological function UCH-L1 is a deubiquitinating enzyme, it binds to and stabilizes mono-ubiquitin in neurons Mus musculus