Cloned (Comment) | Organism |
---|---|
determination of the UCHL1 promoter DNA methylation status and the mechanisms for the heterogeneous UCHL1 expression pattern in renal epithelium and in renal cell carcinoma, overview. Semi-quantitative and real-time RT-PCR analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Homo sapiens | - |
kidney | epithelium | Homo sapiens | - |
kidney cancer cell | different cell lines | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl terminal hydrolase 1 | - |
Homo sapiens |
ubiquitin carboxyl-terminal hydrolase 1 | - |
Homo sapiens |
UCHL1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | promoter hypermethylation represents a mechanism for the silencing of the UCHL1 gene expression in in renal carcinoma cells as a concept of an epigenetic control for the expression of UCHL1 during disease progression. Restoration of UCHL1 expression in renal carcinoma cells by treatment with DAC, overview | down |
Homo sapiens | 2'-deoxy-5-azacytidine, DAC, induces UCHL1 expression in renal carcinoma cell lines linked to the demethylation degree of the UCHL1 promoter DNA. Restoration of UCHL1 expression in renal carcinoma cells by treatment with DAC, overview | up |
General Information | Comment | Organism |
---|---|---|
malfunction | UCHL1 overexpression is associated with tumor progression and an altered von Hippel Lindau gene expression in renal cell carcinoma | Homo sapiens |