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Literature summary for 3.4.19.12 extracted from

  • Cartier, A.E.; Djakovic, S.N.; Salehi, A.; Wilson, S.M.; Masliah, E.; Patrick, G.N.
    Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1 (2009), J. Neurosci., 29, 7857-7868.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information UCH-L1 activity is regulated by synaptic activity. Stimulation of synaptic activity by NMDA/glycine significantly up-regulates UCH-L1 activity in cultured neurons. NMDA-induced up-regulation of UCH-L1 activity is efficiently blocked by pre-treatment of neurons with the NMDA receptor antagonist D-2-amino-5-phosphonopentanoic acid Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
LDN-57444 i.e. 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
dendrite
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Rattus norvegicus 30425
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additional information UCHL1 expression is detected in both soma and dendrites of hippocampal neurons. UCH-L1 is distributed in a micropunctate fashion, localized to dendritic spines of neurons, and partially co-localized with PSD-95, overview Rattus norvegicus
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soluble
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Rattus norvegicus
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synapse
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Rattus norvegicus 45202
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus UCHL1 can act as a ubiquitin hydrolase, and generate free ubiquitin species from precursor ubiquitin polypeptides. Synaptic activation of UCH-L1 is correlated with an increase in the levels of free monomeric ubiquitin ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain specific expression of UCH-L1 Rattus norvegicus
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hippocampus
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Rattus norvegicus
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neuron primary hippocampal neuronal culture Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UCHL1 can act as a ubiquitin hydrolase, and generate free ubiquitin species from precursor ubiquitin polypeptides. Synaptic activation of UCH-L1 is correlated with an increase in the levels of free monomeric ubiquitin Rattus norvegicus ?
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?

Synonyms

Synonyms Comment Organism
More UCH-L1 belongs to a family of de-ubiquitinating enzymes, comprising of UCH-L1-5 Rattus norvegicus
ubiquitin C-terminal hydrolase L1
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Rattus norvegicus
UCH-L1
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Rattus norvegicus

General Information

General Information Comment Organism
malfunction altered UCH-L1 activity leads to deleterious effects on synapse structure and function. Inhibition of UCH-L1 activity affects synaptic protein clusters Rattus norvegicus
physiological function UCH-L1 is one of the major de-ubiquitinating enzymes in the brain which controls ubiquitin homeostasis. UCH-L1 function is required for synaptic plasticity and is itself regulated by synaptic activity. UCH-L1 activity is required for NMDA-induced up-regulation of free monomeric ubiquitin. UCH-L1 can also bind to ubiquitin and act as a ubiquitin stabilizer to prevent its degradation by lysosomes. UCH-L1 regulates spine morphology and density Rattus norvegicus