Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | UCH-L1 is membrane-associated and co-localizes with the ribosomal subunit RPS6 and the ER retention signal KDEL. UCH-L1 is partially co-localized to the site of CFTR protein synthesis | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | UCH-L1 is a deubiquitinating enzyme. UCH-L1 increases the synthesis of cystic fibrosis transmembrane conductance regulator, CFTR, but has little effect on the rate of post-translational degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
IB3-1 cell | a bronchial epithelial cell line, the cells show increased UCH-L1 expression, overview | Homo sapiens | - |
additional information | the deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1, is highly expressed in cystic fibrosis airway epithelial cells in vitro and in vivo | Homo sapiens | - |
S9 cell | a bronchial epithelial cell line, the cells show increased UCH-L1 expression, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UCH-L1 is a deubiquitinating enzyme. UCH-L1 increases the synthesis of cystic fibrosis transmembrane conductance regulator, CFTR, but has little effect on the rate of post-translational degradation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin C-terminal hydrolase-L1 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | elevation in UCH-L1 in cystic fibrosis cells represents a cellular adaptation to counterbalance excessive proteasomal degradation | Homo sapiens |
physiological function | UCH-L1 is a deubiquitinating enzyme. UCH-L1 is a deubiquitinating enzyme. UCH-L1 increases the synthesis of cystic fibrosis transmembrane conductance, and endogenous UCH-L1 expression is positively correlated with CFTR biogenesis | Homo sapiens |