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Literature summary for 3.4.19.12 extracted from

  • Sun, J.; Ying, M.; Li, H.; Shang, X.; He, Y.; Chen, K.; Cheng, H.; Zhou, R.
    Role of UCH-L1/ubiquitin in acute testicular ischemia-reperfusion injury (2008), Biochem. Biophys. Res. Commun., 366, 539-544.
    View publication on PubMed
Search for more literature for 3.4.19.12

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus UCH-L1 expression levels show a time-dependent upregulation in mice ischemia-reperfusion injury condition. Germ cell apoptosis triggers downregulation of UCH-L1 at both mRNA and protein levels, thus, ubiquitination level is impaired. Eevidences of UCH-L1/ubiquitination signaling to the testis ischemia-reperfusion injury in vivo ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9R0P9
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-

Source Tissue

Source Tissue Comment Organism Textmining
germ cell
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 Mus musculus
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spermatocyte
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 Mus musculus
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spermatogonium
-
 Mus musculus
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testis
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 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UCH-L1 expression levels show a time-dependent upregulation in mice ischemia-reperfusion injury condition. Germ cell apoptosis triggers downregulation of UCH-L1 at both mRNA and protein levels, thus, ubiquitination level is impaired. Eevidences of UCH-L1/ubiquitination signaling to the testis ischemia-reperfusion injury in vivo Mus musculus ?
-
 ?
polyubiquitin + H2O
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 Mus musculus ubiquitin
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 ?

Synonyms

Synonyms Comment Organism
ubiquitin carboxyl-terminal hydrolase-L1
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 Mus musculus
UCH-L1
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus germ cell apoptosis after testicular torsion treatment triggers downregulation of UCH-L1 in testis at both mRNA and protein levels down

General Information

General Information Comment Organism
malfunction ubiquitination by UCH-L1 is involved in ischemia-reperfusion stress Mus musculus
physiological function UCH-L1 plays an important role in maintaining the intracellular levels of the ubiquitin Mus musculus