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Literature summary for 3.4.19.12 extracted from
- Split-ubiquitin two-hybrid assay to analyze protein-protein interactions at the endosome: application to Saccharomyces cerevisiae Bro1 interacting with ESCRT complexes, the Doa4 ubiquitin hydrolase, and the Rsp5 ubiquitin ligase (2007), Eukaryot. Cell, 6, 1266-1277.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| doa4delta | defect in endosomal localization | Saccharomyces cerevisiae |
| W782R | is solely cytoplasmic, defect in endosomal localization, Bro1-Doa4 interaction is disrupted | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
| endosome | the C-terminal proline-rich domain of Bro1 participates in recruitment of the Doa4 ubiquitin hydrolase to the endosome | Saccharomyces cerevisiae | 5768 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bro1-Doa4 interaction involves the C-terminal proline-rich domain of Bro1 and a conserved ELC box motif in Doa4 | Saccharomyces cerevisiae | ? | - |
? |  |
| ubiquitin + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Doa4 ubiquitin hydrolase | - |
Saccharomyces cerevisiae |
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