Application | Comment | Organism |
---|---|---|
medicine | targeting the UCH37-Smad7 complex may provide a new approach for treating human diseases in which there is overt up-regulation in TGF-beta signalling activity. Competing effects of ubiquitin ligases and DUBs in complex with Smad7 can serve to fine-tune responses to TGF-betas under various physiological and pathological conditions | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
HEK-293 cells transiently transfected with FLAG (DYKDDDDK)-tagged UCH37 expression construct | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RNAi | knockdown of UCH37, abolishes TGF-beta-dependent transcriptional responses | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
activity-based haemagglutinin-tagged ubiquitin + H2O | - |
Homo sapiens | ? | - |
? | |
Smad2 + H2O | weaker association | Homo sapiens | ? | - |
? | |
Smad3 + H2O | weaker association | Homo sapiens | ? | - |
? | |
Smad7 + H2O | association with Smad7, which can act as an adaptor able to recruit UCH37 to the type I TGF-beta receptor and reverses Smurf-mediated ubiquitination | Homo sapiens | ? | - |
? | |
type I TGF-beta receptor + H2O | UCH37 dramatically up-regulates TGF-beta-dependent gene expression by deubiquitinating and stabilizing the type I TGF-beta receptor | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
de-ubiquitinating enzyme | - |
Homo sapiens |
DUB | - |
Homo sapiens |
ubiquitin C-terminal hydrolase 37 | - |
Homo sapiens |
UCH37 | - |
Homo sapiens |