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Literature summary for 3.4.19.12 extracted from

  • Wicks, S.J.; Grocott, T.; Haros, K.; Maillard, M.; ten Dijke, P.; Chantry, A.
    Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway (2006), Biochem. Soc. Trans., 34, 761-763.
    View publication on PubMed
Search for more literature for 3.4.19.12

Application

Application Comment Organism
medicine targeting the UCH37-Smad7 complex may provide a new approach for treating human diseases in which there is overt up-regulation in TGF-beta signalling activity. Competing effects of ubiquitin ligases and DUBs in complex with Smad7 can serve to fine-tune responses to TGF-betas under various physiological and pathological conditions Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
HEK-293 cells transiently transfected with FLAG (DYKDDDDK)-tagged UCH37 expression construct Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RNAi knockdown of UCH37, abolishes TGF-beta-dependent transcriptional responses Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
activity-based haemagglutinin-tagged ubiquitin + H2O
-
 Homo sapiens ?
-
 ?
Smad2 + H2O weaker association Homo sapiens ?
-
 ?
Smad3 + H2O weaker association Homo sapiens ?
-
 ?
Smad7 + H2O association with Smad7, which can act as an adaptor able to recruit UCH37 to the type I TGF-beta receptor and reverses Smurf-mediated ubiquitination Homo sapiens ?
-
 ?
type I TGF-beta receptor + H2O UCH37 dramatically up-regulates TGF-beta-dependent gene expression by deubiquitinating and stabilizing the type I TGF-beta receptor Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
de-ubiquitinating enzyme
-
 Homo sapiens
DUB
-
 Homo sapiens
ubiquitin C-terminal hydrolase 37
-
 Homo sapiens
UCH37
-
 Homo sapiens