Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Rattus norvegicus | Q00981 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
medulla oblongata | rostral ventrolateral, expression analysis of isozyme UCH-L1 during mevinphos intoxication, overview | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
rostral ventrolateral medulla | de novo synthesis of UCH-L1, leading to an enhanced dissassembly of ubiquitin-protein conjugates in the rostral ventrolateral medulla, is essential to maintenance of the pro-life phase of mevinphos intoxication via prevention of cardiovascular depression, leading to neuroprotection | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl-terminal hydrolase | - |
Rattus norvegicus |
UCH | - |
Rattus norvegicus |
UCH-L1 | - |
Rattus norvegicus |