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Literature summary for 3.4.19.12 extracted from

  • Manago, Y.; Kanahori, Y.; Shimada, A.; Sato, A.; Amano, T.; Sato-Sano, Y.; Setsuie, R.; Sakurai, M.; Aoki, S.; Wang, Y.L.; Osaka, H.; Wada, K.; Noda, M.
    Potentiation of ATP-induced currents due to the activation of P2X receptors by ubiquitin carboxy-terminal hydrolase L1 (2005), J. Neurochem., 92, 1061-1072.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressiom of GFP-tagged wild-type UCH L1 and mutants in PC12 Tet-off cells and in CHO-AA8-Luc1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C90S site-directed mutagenesis, the mutant enzyme lacks C-terminal hydrolase activity but retains ubiquitin binding activity, the mutant shows similar physiological effects in recombinant transfected cells as the wild-type enzyme, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens ubiquitin carboxy-terminal hydrolase L1 activates the P2X receptor leading to potentiation of ATP-induced currents in neurons ?
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?
additional information Rattus norvegicus overexpression of UCH L1 potentiates ATP-induced currents due to the activation of P2X receptors that are widely distributed in the brain and involved in various biological activities including neurosecretion. UCH-L1 may play an important role in synaptic activity ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Homo sapiens
-
neuron
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Homo sapiens
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PC-12 cell
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Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ubiquitin carboxy-terminal hydrolase L1 activates the P2X receptor leading to potentiation of ATP-induced currents in neurons Homo sapiens ?
-
?
additional information overexpression of UCH L1 potentiates ATP-induced currents due to the activation of P2X receptors that are widely distributed in the brain and involved in various biological activities including neurosecretion. UCH-L1 may play an important role in synaptic activity Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
ubiquitin carboxy-terminal hydrolase L1
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Homo sapiens
UCH L1
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Homo sapiens