Protein Variants | Comment | Organism |
---|---|---|
additional information | gad, i.e. gracile axonal dystrophy, mice testis lack isozyme UCH-L1 and are resistant to cryptorchid stress-related injury, the show reduced ubiquitin levels, uchl3 knockout mice show profound testicular atrophy and apoptotic germ cell loss after cryptorchid injury, but unaltered ubiquitin levels compared to wild-type mice, testicular phenotype of mutant mice, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
genes uchl1 and uchl3, C57BL/6J and gad, i.e. gracile axonal dystrophy, mice | - |
Mus musculus | Q9R0P9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
germ cell | - |
Mus musculus | - |
testis | cryptorchid and healthy | Mus musculus | - |
testis | absence of UCH-L1 causes resistance to cryptorchid-induced testicular germ cell apoptosis. UCH-L1 and UXH-L3 have reciprocal functions, with respect to mediating injury after experimental cryptorchidism | Mus musculus | - |
testis | absence of UCH-L3 promotes germ cell apoptosis after cryptorchid injury. UCH-L1 and UXH-L3 have reciprocal functions, with respect to mediating injury after experimental cryptorchidism | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzymes belong to the UCH family | Mus musculus |
ubiquitin C-terminal hydrolase | - |
Mus musculus |
UCH | - |
Mus musculus |
UCH-L1 | - |
Mus musculus |
UCH-L3 | - |
Mus musculus |