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Literature summary for 3.4.17.23 extracted from

  • Rutkowska-Zapala, M.; Suski, M.; Szatanek, R.; Lenart, M.; Weglarczyk, K.; Olszanecki, R.; Grodzicki, T.; Strach, M.; Gasowski, J.; Siedlar, M.
    Human monocyte subsets exhibit divergent angiotensin I-converting activity (2015), Clin. Exp. Immunol., 181, 126-132 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
 DRVYIHPFH + L-Leu
-
 ?
angiotensin II + H2O Homo sapiens
-
 DRVYIHP + L-Phe
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel
-
 Homo sapiens
-
monocyte classical, CD14++CD16- cells Homo sapiens
-
additional information highest relative level of ACE2 mRNA expression is observed in CD14++CD16- (classical) monocytes. In peripheral blood mononuclear cells (PBMC), monocytes and classical monocytes, ACE2 protein expression is stronger compared to other monocyte subpopulations. ACE1 (EC 3.4.15.1) expression is slightly more diverse than ACE2 levels, immune cell expression analysis Homo sapiens
-
peripheral blood mononuclear cell PBMC Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Homo sapiens DRVYIHPFH + L-Leu
-
 ?
angiotensin II + H2O
-
 Homo sapiens DRVYIHP + L-Phe
-
 ?

Synonyms

Synonyms Comment Organism
ACEII
-
 Homo sapiens
angiotensin-converting enzyme type 2
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in the renin-angiotensin system (RAS), which includes angiotensin I, angiotensin (Ang)II, and peptides angiotensin-(1-9) and angiotensin-(1-7) derived by C-terminal cleavage of their particular antecessors by angiotensin converting enzyme (ACE)1 or ACE2, overview Homo sapiens
physiological function the enzyme is involved in the renin-angiotensin system (RAS), which includes angiotensin I, angiotensin (Ang)II, and peptides angiotensin-(1-9) and angiotensin-(1-7) derived by C-terminal cleavage of their particular antecessors by angiotensin converting enzyme (ACE)1 or ACE2, overview Homo sapiens