Organism | UniProt | Comment | Textmining |
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Canis lupus familiaris | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
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General Information | Comment | Organism |
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physiological function | atrial ACE2 overexpression attenuates rapid atrial pacing-induced increase in activated extracellular signal-regulated kinases and mitogen-activated protein kinases levels, and decrease in MAPK phosphatase 1 level, resulting in attenuation of atrial fibrosis collagen protein markers and transforming growth factor-beta1. ACE2 overexpression also modulates the tachypacing-induced up-regulation of connexin 40, down-regulation of connexin 43 and Kv4.2, and significantly decreases the inducibility and duration of atrial fibrillation | Canis lupus familiaris |