Cloned (Comment) | Organism |
---|---|
ACE2 expression analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Homo sapiens | - |
angiotensin(1-7) + L-Phe | - |
? | |
angiotensin II + H2O | Homo sapiens | - |
angiotensin(1-7) + L-Phe | Ang-(17) is a potential endogenous inhibitor of the classical renin-angiotensin system cascade | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYF1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiofibroblast | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | - |
Homo sapiens | angiotensin(1-7) + L-Phe | - |
? | |
angiotensin II + H2O | - |
Homo sapiens | angiotensin(1-7) + L-Phe | Ang-(17) is a potential endogenous inhibitor of the classical renin-angiotensin system cascade | ? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Homo sapiens |
angiotensin converting enzyme II | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | angiotensin peptides modulate the expression of angiotensin converting enzyme II in the cardiovascular system, angiotensin II upregulates ACE2, modulated through activation of Ang II type 1 receptor, AT1R, and increases Ang-(1-7) formation from Ang II, and ACE2 expression is further enhanced by Ang-(1-7) in a positive feedback loop, molecular mechanism, overview. The upregulation is inhibited by Ang-(1-7) Mas receptor blockade through PD98059 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | ACE2 reduces the generation of Ang II by catalyzing the conversion of Ang I to angiotensin-(1-9) and facilitating the hydrolysis of Ang II to angiotensin-(1-7) | Homo sapiens |