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Literature summary for 3.4.17.23 extracted from

  • Lin, C.S.; Pan, C.H.; Wen, C.H.; Yang, T.H.; Kuan, T.C.
    Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts (2010), Peptides, 31, 1334-1340.
    View publication on PubMed
Search for more literature for 3.4.17.23

Cloned(Commentary)

Cloned (Comment) Organism
ACE2 expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Homo sapiens
-
 angiotensin(1-7) + L-Phe
-
 ?
angiotensin II + H2O Homo sapiens
-
 angiotensin(1-7) + L-Phe Ang-(1–7) is a potential endogenous inhibitor of the classical renin-angiotensin system cascade ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiofibroblast
-
 Homo sapiens
-
heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
 Homo sapiens angiotensin(1-7) + L-Phe
-
 ?
angiotensin II + H2O
-
 Homo sapiens angiotensin(1-7) + L-Phe Ang-(1–7) is a potential endogenous inhibitor of the classical renin-angiotensin system cascade ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Homo sapiens
angiotensin converting enzyme II
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens angiotensin peptides modulate the expression of angiotensin converting enzyme II in the cardiovascular system, angiotensin II upregulates ACE2, modulated through activation of Ang II type 1 receptor, AT1R, and increases Ang-(1-7) formation from Ang II, and ACE2 expression is further enhanced by Ang-(1-7) in a positive feedback loop, molecular mechanism, overview. The upregulation is inhibited by Ang-(1-7) Mas receptor blockade through PD98059 up

General Information

General Information Comment Organism
physiological function ACE2 reduces the generation of Ang II by catalyzing the conversion of Ang I to angiotensin-(1-9) and facilitating the hydrolysis of Ang II to angiotensin-(1-7) Homo sapiens