Activating Compound | Comment | Organism | Structure |
---|---|---|---|
XNT | activates ACE2, reduces platelet attachment to injured vessels, reduces thrombus size, and prolonges the time for complete vessel occlusion in mice. Thrombus area is reduced by 60%, whereas time for thrombus formation is prolonged by 45% in XNT-treated mice | Mus musculus | |
XNT | treatment at 10 mg/kg resultes in a 30% attenuation of thrombus formation in the SHR | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DX600 | a decrease in thrombus ACE2 activity is associated with increased thrombus formation in nude mice | Mus musculus | |
DX600 | a decrease in thrombus ACE2 activity is associated with increased thrombus formation in spontaneously hypertensive rats | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Mus musculus | |
Zn2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Mus musculus | angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor | angiotensin(1-7) + L-Phe | - |
? | |
angiotensin II + H2O | Rattus norvegicus | angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor | angiotensin(1-7) + L-Phe | - |
? | |
additional information | Mus musculus | ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue | ? | - |
? | |
additional information | Rattus norvegicus | ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
nude mice | - |
Rattus norvegicus | - |
spontaneously hypertensive rats and Wistar Kyoto rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood vessel | - |
Mus musculus | - |
blood vessel | - |
Rattus norvegicus | - |
skin | - |
Mus musculus | - |
skin | - |
Rattus norvegicus | - |
vena cava | induced thrombus | Mus musculus | - |
vena cava | induced thrombus. No differences between spontaneously hypertensive rats and Wistar Kyoto rats in ACE2 protein and ACE activity in the thrombi | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-methoxycoumarin-4-acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl)-OH + H2O | - |
Mus musculus | ? | - |
? | |
7-methoxycoumarin-4-acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl)-OH + H2O | - |
Rattus norvegicus | ? | - |
? | |
7-methoxycoumarin-4-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys-(2,4-dinitrophenyl)-OH + H2O | - |
Mus musculus | ? | - |
? | |
7-methoxycoumarin-4-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-Lys-(2,4-dinitrophenyl)-OH + H2O | - |
Rattus norvegicus | ? | - |
? | |
angiotensin II + H2O | i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | Mus musculus | angiotensin(1-7) + L-Phe | i.e. Asp-Arg-Val-Tyr-Ile-His-Pro | ? | |
angiotensin II + H2O | i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | Rattus norvegicus | angiotensin(1-7) + L-Phe | i.e. Asp-Arg-Val-Tyr-Ile-His-Pro | ? | |
angiotensin II + H2O | angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor | Mus musculus | angiotensin(1-7) + L-Phe | - |
? | |
angiotensin II + H2O | angiotensin II has many adverse cardiovascular effects when acting through the AT1 receptor | Rattus norvegicus | angiotensin(1-7) + L-Phe | - |
? | |
additional information | ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue | Mus musculus | ? | - |
? | |
additional information | ACE2 activation promotes antithrombotic activity. ACE2 is an ACE, EC 3.4.15.1, homologue | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Mus musculus |
ACE2 | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
7.5 | - |
assay at | Rattus norvegicus |