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Literature summary for 3.4.17.23 extracted from

  • Stewart, J.M.; Ocon, A.J.; Clarke, D.; Taneja, I.; Medow, M.S.
    Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome (2009), Hypertension, 53, 767-774.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Ac-GDYSHCSPLRYYPWWPDPEGGG-NH2 i.e. DX600 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Homo sapiens
-
angiotensin(1-7) + L-Phe
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
Homo sapiens angiotensin(1-7) + L-Phe
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens

General Information

General Information Comment Organism
malfunction postural tachycardia syndrome is associated with increased plasma angiotensin-II. ACE2 effects are blunted in low flow postural tachycardia syndrome, POTS, and restored by the ACE2 product angiotensin-(1-7) Homo sapiens
physiological function ACE2 is involved in the angiotensin-II-mediated vasodilation Homo sapiens