Activating Compound | Comment | Organism | Structure |
---|---|---|---|
losartan | an angiotensin II type 1 receptor blocker, increases central ACE2 activity. Losartan also restores brain ACE2 activity in transgenic RA mice, overview | Mus musculus | |
additional information | no activation by PD123319, an angiotensin II type 2 antagonist | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of triple-transgenic-model mice with brain ACE2 overexpression on a chronically hypertensive, AngII-increased background. The transgenic mice show dramatically decreased baseline spontaneous baroreflex sensitivity and brain ACE2 activity compared with nontransgenic mice, whereas peripheral ACE2 activity/expression remains unaffected | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | central angiotensin II type 1 receptors reduce ACE2 expression/activity in hypertensive mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Mus musculus | - |
angiotensin(1-7) + L-Phe | Ang(1-7) is a vasodilator peptide | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | - |
Mus musculus | angiotensin(1-7) + L-Phe | - |
? | |
angiotensin II + H2O | - |
Mus musculus | angiotensin(1-7) + L-Phe | Ang(1-7) is a vasodilator peptide | ? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | central angiotensin II type 1 receptors reduce ACE2 expression/activity in hypertensive mice | down |
General Information | Comment | Organism |
---|---|---|
malfunction | angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice | Mus musculus |
physiological function | ACE2 is a component of the brain renin-angiotensin system participating in the central regulation of blood pressure | Mus musculus |