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Literature summary for 3.4.17.23 extracted from

  • Clayton, D.; Hanchapola, I.; Perlmutter, P.; Smith, A.I.; Aguilar, M.I.
    The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and beta-amino acid substrate analogs (2009), Adv. Exp. Med. Biol., 611, 559-560.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
angiotensin II C-terminal analogs screening of a library of angiotensin II C-terminal analogs identifies a number of tetrapeptides with increased ACE2 inhibition, and identifies residues critical to the binding of angiotensin II to the active site of ACE2 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc carboxypeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Homo sapiens the enzyme is involved in the renin angiotensin system angiotensin-(1-7) + L-Phe
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart the enzyme is upregulated in cardiovascular disease Homo sapiens
-
liver the enzyme is upregulated in fibrotic liver Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + L-Phe
-
?
angiotensin II + H2O the enzyme is involved in the renin angiotensin system Homo sapiens angiotensin-(1-7) + L-Phe
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens
angiotensin II converting enzyme 2
-
Homo sapiens