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Literature summary for 3.4.17.23 extracted from

  • Lew, R.A.; Warner, F.J.; Hanchapola, I.; Yarski, M.A.; Manohar, J.; Burrell, L.M.; Smith, A.I.
    Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor (2008), Exp. Physiol., 93, 685-693.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK 293-T cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Cu2+ 69% inhibition at 0.01 mM Homo sapiens
MLN-4760 0.0001 mM Homo sapiens
additional information not inhibited by Ca2+, Cd2+, Co2+, Mg2+, Mn2+, and Zn2+ Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni3+-charged nitrilotriacetic acid-linked resin chromatography and and anti-Flag column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma ACE2 circulates in human plasma, but its activity is suppressed by the presence of an endogenous inhibitor Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)-acetyl-Ala-Pro-Lys(2,4-dinitrophenyl) + H2O
-
Homo sapiens (7-methoxycoumarin-4-yl)-acetyl-Ala-Pro + N6-(2,4-dinitrophenyl)-L-Lys
-
?
angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + Phe
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.005
-
-
Homo sapiens Cu2+