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Literature summary for 3.4.17.23 extracted from

  • Ho, T.Y.; Wu, S.L.; Chen, J.C.; Li, C.C.; Hsiang, C.Y.
    Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction (2007), Antiviral Res., 74, 92-101.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3,8-trihydroxy-6-methylanthraquinone 1,3,8-trihydroxy-6-methylanthraquinone (emodin) blocks interaction between the SARS corona virus spike protein and its receptor angiotensin-converting enzyme 2, 94.12% inhibition at 0.05 mM Homo sapiens
1,4-bis-(1-anthraquinonylamino)-anthraquinone slight inhibition Homo sapiens
1,8,dihydroxy-3-carboxyl-9,10-anthraquinone 1,8,dihydroxy-3-carboxyl-9,10-anthraquinone (rhein) exhibits slight inhibition Homo sapiens
5,7-dihydroxyflavone 5,7-dihydroxyflavone (chrysin) is a weak inhibitor Homo sapiens
anthraquinone slight inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
Homo sapiens angiotensin-(1-7) + Phe
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.2
-
-
Homo sapiens 1,3,8-trihydroxy-6-methylanthraquinone