Literature summary for 3.4.17.23 extracted from

Li, N.; Zimpelmann, J.; Cheng, K.; Wilkins, J.A.; Burns, K.D.
The role of angiotensin converting enzyme 2 in the generation of angiotensin 1-7 by rat proximal tubules (2005), Am. J. Physiol. Renal Physiol., 288, F353-F362.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensin I + H2O	Rattus norvegicus	ACE2 contributes to the production of angiotensin(1-7) from angiotensin I in proximal straight tubule	angiotensin-(1-9) + Leu	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	ACE2 mRNA is widely expressed, with relatively high levels in proximal straight tubule. ACE2 protein is present in tubular segments, glomeruli and endothelial cells. No activity in medullary thick ascending limb of henle's loop	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin I + H2O	ACE2 contributes to the production of angiotensin(1-7) from angiotensin I in proximal straight tubule	Rattus norvegicus	angiotensin-(1-9) + Leu	-	?

Synonyms

Synonyms	Comment	Organism
ACE2	-	Rattus norvegicus
angiotensin converting enzyme 2	-	Rattus norvegicus

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Release 2023.1 (January 2023)