Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.23 extracted from

  • Dantas, A.P.; Sandberg, K.
    Regulation of ACE2 and ANG-(1-7) in the aorta: New insights into the renin-angiotensin system in the control of vascular function (2005), Am. J. Physiol., 289, H980-H981.
    View publication on PubMed

Application

Application Comment Organism
medicine chronic treatment with the AT1R antagonist almesartan induces a fivefold increase in ACE2 mRNA in the aorta which leads to a significant increase in aortic angiotensin(1-7) protein expression. These effects are associated with significant decreases in aortic medial thickness and may represent an important protective mechanism in the prevention of cardiovascular events in hypertensive subjects Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
spontaneously hypertensive rat
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta thoracica chronic treatment with the AT1R antagonist almesartan induces a fivefold increase in ACE2 mRNA in the aorta which leads to a significant increase in aortic angiotensin(1-7) protein expression Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
ACE
-
Rattus norvegicus