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Literature summary for 3.4.17.23 extracted from

  • Donoghue, M.; Hsieh, F.; Baronas, E.; Godbout, K.; Gosselin, M.; Stagliano, N.; Donovan, M.; Woolf, B.; Robison, K.; Jeyaseelan, R.; Breitbart, R.E.; Acton, S.
    A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 (2000), Circ. Res., 87, E1-9.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by captopril Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
angiotensin-(1-9) + Leu
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant from CHO K1 cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelium of coronary and intrarenal vessels and renal tubuls Homo sapiens
-
heart ventricle
-
Homo sapiens
-
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
Homo sapiens angiotensin-(1-9) + Leu
-
?
angiotensin I + H2O no angiotensin-converting activity, i.e. no conversion of the decapeptide angiotensin I to the octapeptide angiotensin II Homo sapiens angiotensin-(1-9) + Leu
-
?

Synonyms

Synonyms Comment Organism
ACE-related carboxypeptidase
-
Homo sapiens
ACE2
-
Homo sapiens