Cloned (Comment) | Organism |
---|---|
gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by captopril | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | metalloprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Homo sapiens | - |
angiotensin-(1-9) + Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYF1 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant from CHO K1 cells | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | of coronary and intrarenal vessels and renal tubuls | Homo sapiens | - |
heart ventricle | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Homo sapiens | angiotensin-(1-9) + Leu | - |
? | |
angiotensin I + H2O | no angiotensin-converting activity, i.e. no conversion of the decapeptide angiotensin I to the octapeptide angiotensin II | Homo sapiens | angiotensin-(1-9) + Leu | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE-related carboxypeptidase | - |
Homo sapiens |
ACE2 | - |
Homo sapiens |