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Literature summary for 2.4.1.17 extracted from

  • Mano, Y.; Usui, T.; Kamimura, H.
    The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver (2007), Drug Metab. Dispos., 35, 2040-2044.
    View publication on PubMed
Search for more literature for 2.4.1.17

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information enzyme kinetics with substrate gemfibrozil follow Michaelis-Menten kinetics Homo sapiens
0.0022
-
 gemfibrozil pH 7.5, 37°C, isozyme UGT2B7 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-D-glucuronate + acceptor Homo sapiens
-
 UDP + acceptor beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + estradiol Homo sapiens isozymes UGT1A1 and UGT1A9 UDP + estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + flurbiprofen Homo sapiens isozyme UGT2B7 UDP + flurbiprofen beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + gemfibrozil Homo sapiens gemfibrozil is a fibrate hypolipidemic agent, isozyme UGT2B7 in the liver UDP + gemfibrozil beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + morphine Homo sapiens isozyme UGT2B7 UDP + morphine 3-O-beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + propofol Homo sapiens isozymes UGT1A1 and UGT1A9 UDP + propofol beta-D-glucuronoside
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 diverse isozymes
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + estradiol isozymes UGT1A1 and UGT1A9 Homo sapiens UDP + estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + flurbiprofen isozyme UGT2B7 Homo sapiens UDP + flurbiprofen beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + gemfibrozil gemfibrozil is a fibrate hypolipidemic agent, isozyme UGT2B7 in the liver Homo sapiens UDP + gemfibrozil beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + gemfibrozil activity with isozymes UGT1A1, UGT1A3, UGT1A9, UGT2B4, UGT2B7, UGT2B17, and especially with isozyme UGT2B7 showing the highest activity Homo sapiens UDP + gemfibrozil beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + morphine isozyme UGT2B7 Homo sapiens UDP + morphine 3-O-beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + propofol isozymes UGT1A1 and UGT1A9 Homo sapiens UDP + propofol beta-D-glucuronoside
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens