Literature summary for 2.1.1.57 extracted from

Toczydlowska-Socha, D.; Zielinska, M.M.; Kurkowska, M.; Astha, M.; Almeida, C.F.; Stefaniak, F.; Purta, E.; Bujnicki, J.M.
Human RNA cap1 methyltransferase CMTr1 cooperates with RNA helicase DHX15 to modify RNAs with highly structured 5 termini (2018), Philos. Trans. R. Soc. Lond. B Biol. Sci., 373, 20180161 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
ATP-dependent RNA DHX15 helicase	the enzyme acts poorly on capped RNA molecules whose 5'-terminal residues are base-paired to form secondary structure. However, the enzyme uses its G-patch domain to form a strong complex with ATP-dependent RNA, which significantly improves the efficiency of cap1 methylation of such RNAs	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in High Five insect cells and HEK-293 cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA]	Homo sapiens	-	S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
HiTrap heparin column chromatography and HIS Select nickel affinity gel filtration and HiTrap Q column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA]	-	Homo sapiens	S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA]	-	?

Subunits

Subunits	Comment	Organism
?	x * 95000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
CMTr1	-	Homo sapiens
RNA cap1 methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)