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Literature summary for 2.1.1.57 extracted from

  • Zhang, X.; Wei, Y.; Ma, Y.; Hu, S.; Li, J.
    Identification of aromatic amino acid residues in conserved region VI of the large polymerase of vesicular stomatitis virus is essential for both guanine-N-7 and ribose 2-O methyltransferases (2010), Virology, 408, 241-252.
    View publication on PubMed
Search for more literature for 2.1.1.57

Protein Variants

Protein Variants Comment Organism
E1674A the mutation in the V1 region of L protein abolishes 2'-O methylation activity vesicular stomatitis virus
E1674D the mutation in the V1 region of L protein shows severely reduced 2'-O methylation activity (about 20%) compared to the wild type vesicular stomatitis virus
E1674K the mutation in the V1 region of L protein shows severely reduced 2'-O methylation activity (about 15%) compared to the wild type vesicular stomatitis virus
E1674Q the mutation in the V1 region of L protein shows severely reduced 2'-O methylation activity (about 15%) compared to the wild type vesicular stomatitis virus
F1691A the mutation in the V1 region of L protein abolishes 2'-O methylation activity vesicular stomatitis virus
F1691W the mutation in the V1 region of L protein shows slightly reduced 2'-O methylation activity (about 78%) compared to the wild type vesicular stomatitis virus
F1691Y the mutation in the V1 region of L protein shows slightly reduced 2'-O methylation activity (about 80%) compared to the wild type vesicular stomatitis virus
Y1650A the mutation in the V1 region of L protein abolishes 2'-O methylation activity vesicular stomatitis virus
Y1650F the mutation in the V1 region of L protein shows slightly reduced 2'-O methylation activity (about 85%) compared to the wild type vesicular stomatitis virus
Y1650W the mutation in the V1 region of L protein shows slightly reduced 2'-O methylation activity (about 90%) compared to the wild type vesicular stomatitis virus

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine complete inhibition at 1 mM vesicular stomatitis virus

Organism

Organism UniProt Comment Textmining
vesicular stomatitis virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + m7G(5')pppA-RNA
-
 vesicular stomatitis virus S-adenosyl-L-homocysteine + m7G(5')pppAm-RNA
-
 ?
S-adenosyl-L-methionine + m7G(5')pppN-RNA
-
 vesicular stomatitis virus S-adenosyl-L-homocysteine + m7G(5')pppNm-RNA
-
 ?

Synonyms

Synonyms Comment Organism
2'-O MTase
-
 vesicular stomatitis virus
L protein domain VI
-
 vesicular stomatitis virus
large polymerase protein domain VI
-
 vesicular stomatitis virus
ribose 2'-O methyltransferase
-
 vesicular stomatitis virus