Protein Variants | Comment | Organism |
---|---|---|
R264C | single nuclotide polymorphism, impairs the correct binding of both substrate and inhibitor molecules. contrary to wild-type, mutant undergoes a less efficient packing process, suggesting a minor flexibility of the mobile segments | Homo sapiens |
R264H | single nuclotide polymorphism, impairs the correct binding of both substrate and inhibitor molecules. contrary to wild-type, mutant undergoes a less efficient packing process, suggesting a minor flexibility of the mobile segments | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11511 | - |
- |
General Information | Comment | Organism |
---|---|---|
metabolism | CYP19A1 protein structure is organized in two main clusters, whose connectivity is altered by ligand binding. Upon substrate or inhibitor binding, the wild-type enzyme undergoes a conformational change leading to a more compact tertiary structure. In single-nucleotide polymorphisms R264C and R264H the exchange rates in the ligand-free and -bound forms are similar, and the quenching effect on tryptophan-224 observed upon ligand binding in the wild-type, is absent in both variants. Helices F and G between the two clusters that form the substrate channel to the active site have a connecting role | Homo sapiens |