Literature summary for 1.13.11.25 extracted from

Nozaki, M.
Nonheme iron dioxygenase (1974), Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York, , 135-165.

No PubMed abstract available

Search for more literature for 1.13.11.25

General Stability

General Stability	Organism
acetone stabilizes	Rhodococcus equi

Inhibitors

Inhibitors	Comment	Organism	Structure
2,2'-dipyridyl	noncompetitive inhibition	Rhodococcus equi
4-hydroxymercuribenzoate	1 mM, 87% inhibition after 10 min	Rhodococcus equi
4-Isopropylcatechol	competitive vs. organic substrate, uncompetitive vs. O2	Rhodococcus equi
8-hydroxyquinoline	1 mM, 90% inhibition after 10 min, noncompetitive inhibition	Rhodococcus equi
o-phenanthroline	1 mM, 68% inhibition after 10 min, noncompetitive inhibition	Rhodococcus equi
sodium iodoacetate	1 mM, 70% inhibition after 10 min	Rhodococcus equi

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	1.13 gatom per mol of enzyme, stimulation of reaction	Rhodococcus equi

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
286000	-	-	Rhodococcus equi

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2	Rhodococcus equi	-	3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rhodococcus equi	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate	proximal extradiol cleavage	Rhodococcus equi	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2	-	Rhodococcus equi	3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate	-	?
3-isopropylcatechol + O2	-	Rhodococcus equi	?	-	?
3-tert-butyl-5-methylcatechol + O2	-	Rhodococcus equi	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)